Influenza

The protein, HMGB1, was previously hypothesized to block DNA repair, senior author Karen Vasquez, Ph.D., associate professor in M. D. Anderson’s Department of Carcinogenesis at the Science Park – Research Division in Smithville, Texas. Identification and repair of DNA damage is the frontline defense against the birth and reproduction of mutant cells that cause cancer [...]

The missing link is a well–studied mammalian protein called SIRT1, which was previously known to be switched on and off in accordance with cells’ metabolic state and is perhaps best known for its potential life-extending properties. "We all have noticed in an intuitive manner that the body requires more energy at certain times of day," [...]

The missing link is a well–studied mammalian protein called SIRT1, which was previously known to be switched on and off in accordance with cells’ metabolic state and is perhaps best known for its potential life-extending properties. "We all have noticed in an intuitive manner that the body requires more energy at certain times of day," [...]

The study sets a new standard for analysing the evolution and spread of a disease-causing bacterium: it is the first study of multiple samples of any bacterial pathogen at this level of detail. It uncovers previously hidden genetic signatures of the evolution of individual lineages of Salmonella Typhi. The team developed methods that are being [...]

Blocking HIV multiplication in patients is an important field of investigation in the fight against AIDS. One of the main goals of this research is to develop synthetic drugs capable of preventing viral replication after infection. For multiplication, the virus must duplicate its genetic material during a process called replication. During replication, several important cellular [...]

CRD represents a heterogeneous set of disorders characterized by progressive loss of retinal cone function. As these photoreceptor cells allow us to see in bright light, loss of cones results in what is commonly known as dayblindness, and can advance to blindness altogether. Thus far, investigations into the genetic basis for autosomal recessively inherited cases [...]

The discovery, published August 11 in the international journal Cancer Cell, provides valuable insights into how cancer cells develop and mutate, and could ultimately change treatment options for sufferers around the world. Team leader, Associate Professor Tony Tiganis, from the Department of Biochemistry and Molecular Biology at Monash University said their work showed that the [...]

In a review published in Disease Models & Mechanisms (DMM), genetics researchers from Yale University School of Medicine and Fudan University School of Life Sciences discuss the history and future of mice as a model organism. They predict that the next frontiers in mouse genetics – such as creating mice expressing human genes to create [...]

Cleft palate is one of the most common congenital birth defects, occurring in one out of every 700 live births. Clefts are more common in children of American Indian, Hispanic or Asian descent. While males are twice as likely to have a cleft lip, females are twice as likely to have a cleft palate. But [...]

Because of its specificity to the cardiovascular system, this "microRNA" is an attractive potential target for therapeutic treatment, the researchers said. "Manipulating this microRNA provides a completely new way of addressing cardiovascular disorders," said Dr. Eric Olson, chairman of molecular biology and senior author of a study appearing in Developmental Cell, August 12. MicroRNAs are [...]